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I have been using Mirapex for almost a year now. Before that, I used Requip. I take a half dose twice a day. A single dose a day does not make 24 hours. This makes 12 hour shift work tolerable as far as the RLS.

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Pramipexole and levodopa both ameliorate the motor symptoms of early Parkinson disease (PD), but no controlled studies have compared long-term outcomes after initiating dopaminergic therapy with pramipexole vs levodopa.

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CYP interactions: Inhibitors of cytochrome P450 enzymes would not be expected to affect pramipexole elimination because pramipexole is not appreciably metabolized by these enzymes in vivo or in vitro.

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Prolonged-release levodopa preparations (ideally taken at bedtime).

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COMT inhibitors (eg, entacapone) can be used to prolong the action of levodopa and increase the 'on time', reduce the levodopa dose and modestly improve motor impairment and disability.

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